Full-scale scaffold model of the human hippocampus CA1 area

Abstract The increasing availability of quantitative data on the human brain is opening new avenues to study neural function and dysfunction, thus bringing us closer implementation digital twin applications for personalized medicine. Here we provide a resource neuroscience community: computational method generate full-scale scaffold model regions starting from microscopy images. We have benchmarked reconstruct CA1 region right hippocampus, which accounts about half entire hippocampal formation. Together with 3D soma positioning connectivity matrix generated using morpho-anatomical connection strategy based axonal dendritic probability density functions accounting morphological properties neurons. algorithms are supplied in ready-to-use format, suited implement models at different scales detail.